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'Grey's Anatomy' Season 10 Spoilers: New Episode 'Do You Know' Brings Sandra Oh's Exit Closer

"Grey's Anatomy" season 10 returns to ABC this week with an installment entitled "Do You Know," drawing Sandra Oh's exit even nearer.

The actress is leaving the medical drama after a decade of portraying fan favorite Dr. Cristina Yang. While "Grey's" creator has already promised viewers that Oh will get "the exit she deserves," fans are anxiously awaiting details on the actress' final episode.

However, fans have even more to anticipate from season 11 of the hit show. According to spoilers this week, characters Shane Ross and Leah Murphy are also leaving "Grey's Anatomy" during season 10. Actors Gaius Charles and Tessa Ferrer have been forced out of their regular roles on the show after ABC did not renew their contracts, according to Deadline.

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Ferrer's Leah is a second-year resident on "Grey's" who has been involved with Alex (Justin Chambers) and Arizona (Jessica Capshaw). Alternately, Shane is also a resident. He has been romantically linked to Stephanie (Jerikka Hinton) and Cristina (Sandra Oh). It is unclear if the characters will make guest appearances in the future.

Meanwhile, "Grey's" mainstays Ellen Pompeo and Patrick Dempsey have both confirmed that they will continue to star on the medical drama next season.

"Grey's has been such a remarkable ride," Dempsey told TVLine back in August. "Shonda [Rhimes] has been incredibly supportive. I enjoy Grey's more than ever in many ways. Our relationship has grown considerably. We've all matured of the last 10 years. So it would be a shame to end this."

While Dempsey will remain on "Grey's" as Dr. Derek Shepherd, the actor recounted the moment he learned that Oh was leaving the series.

"We found out right at the end of the table read for the 200th episode," Dempsey recalled. "She took the cast aside individually and said, 'I'm going to leave the show.' With any member of the show, especially the original cast, it's always sad to see someone leave."

"Grey's Anatomy" airs on ABC Thursdays at 9 p.m. EST. The synopsis for this week's "Do You Know" on TV Guide is as follows: "Cristina envisions two different scenarios for her life based on one crucial decision she faces. Meanwhile, a patient decides whether to live or die."

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